Citation: Zhang Qianwen, Liu Yang, Li Jian, Xia Xinghua. Revealing the kinetics of ionophore facilitating ion transport across lipid bilayers by surface enhanced infrared absorption spectroscopy[J]. Chinese Chemical Letters, ;2020, 31(2): 479-481. doi: 10.1016/j.cclet.2019.08.009 shu

Revealing the kinetics of ionophore facilitating ion transport across lipid bilayers by surface enhanced infrared absorption spectroscopy

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

xhxia@mail.nju.edu.cn

Received Date: 6 July 2019
Revised Date: 2 August 2019
Accepted Date: 6 August 2019
Available Online: 6 August 2019

Figures(5)

Ionophore can prominently improve the ion permeability of cell membrane and disrupt cellular ion homeostasis. Most studies regarding ionophore facilitating ion transmembrane transport focus on artificial liquid-liquid interfaces, which have large difference from the actual environment of cell membrane. Here, we construct a supported lipid bilayer on a gold nanoparticles film modified ZnSe prism as an appropriate model of cell membrane to investigate the dynamic of the ion transport facilitated by ionophore using surface enhanced infrared absorption spectroscopy (SEIRAS). We find that the ion transmembrane transport consists of two steps: The ion transmembrane transport starts with the association/disassociation between ion and ionophore at the edge of lipid bilayer; The second step is the transfer of ion-ionophore complex across lipid bilayer. Our results show that the complex transfer across the lipid bilayer is the rate determining step.
- SEIRAS,
- Ion transmembrane transport,
- Ionophore,
- Kinetics,
- Supported lipid bilayers
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