Citation: Yang Jinlong, Dong Zirong, Liu Wenjuan, He Haisheng, Fan Wufa, Lu Yi, Wu Wei, Gan Li, Qi Jianping. Discriminating against injectable fat emulsions with similar formulation based on water quenching fluorescent probe[J]. Chinese Chemical Letters, ;2020, 31(3): 875-879. doi: 10.1016/j.cclet.2019.07.016 shu

Discriminating against injectable fat emulsions with similar formulation based on water quenching fluorescent probe

Yang Jinlong ^a,b ,
Dong Zirong ^b ,
Liu Wenjuan ^b ,
He Haisheng ^b ,
Fan Wufa ^b ,
Lu Yi ^b ,
Wu Wei ^b ,
Gan Li ^a,*, ,
Qi Jianping ^b,*,

a.
Department of Pharmaceutical Engineering, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China
b.
Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China

sit2016@vip.sina.com.cn

qijianping@fudan.edu.cn

Received Date: 18 May 2019
Revised Date: 1 July 2019
Accepted Date: 2 July 2019
Available Online: 8 July 2019

Figures(6)

The discrimination against nutritional fat emulsion injections was considered by imaging tools, which aims to elucidate the in vivo behaviors of nanoemulsions. In this study, 20% nutritional fat emulsion injections were selected from different company including original and generic products. Meanwhile, a water quenching fluorescent probe (P2) was used to label them by an incubation method. The fluorescent intensity analysis of blood-borne fluorescence reveals rapid clearance of nanoemulsion in all groups, which shows 'L'-type blood kinetic profiles. However, these kinetic parameters do not have significant difference. Following intravenous administration, the nanoemulsions in all groups concomitantly accumulated in organs of reticulo-endothelial system (RES), such as liver and spleen, and were cleared from body circulation mostly after 12 h. AUC_(0-t) of organs from different groups showed dissimilar results in some organs. These intuitional results are of significance in understanding the in vivo behaviors of nanoemulsions, which can provide a new way to discriminate against nutritional fat emulsions.
- In vivo discrimination,
- Fat emulsions,
- Environment-responsive,
- Fluorescent probe,
- Similarity
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