Citation: Cheng Xuejing, Li Mengyu, Wang Hui, Cheng Yiyun. All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation[J]. Chinese Chemical Letters, ;2020, 31(3): 869-874. doi: 10.1016/j.cclet.2019.07.013 shu

All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation

Cheng Xuejing ^a ,
Li Mengyu ^a ,
Wang Hui ^b,*, ,
Cheng Yiyun ^a,b,**,

a.
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China
b.
South China Advanced Institute for Soft Matter Science and Technology, South China University of Technology, Guangzhou 510640, China

^**

wangh@scut.edu.cn

yycheng@mail.ustc.edu.cn

Received Date: 6 June 2019
Revised Date: 29 June 2019
Accepted Date: 4 July 2019
Available Online: 4 July 2019

Figures(5)

Reversible boronate-catechol linkage was widely used to construct two-dimensional coatings and threedimensional nanostructures or hydrogels. The construction of these functional materials usually requires the pre-synthesis of macromolecular building blocks, and direct gelation between natural polyphenols and small molecule boronic acids is yet to be investigated. In this study, we fabricated a family of allsmall-molecule dynamic covalent gels consisting of tannic acid and boronic acids. Transparent and thixotropic gels were formed by boronate affinity towards catechol groups abundant on natural polyphenols. The gels showed multi-responsiveness, such as acid-, base-, reduction-and oxidantsensitive depending on the used boronic acid building blocks. The chemistry for gel formation and stimuli-responsiveness was characterized by 11B NMR spectroscopy. The multi-stimuli responsiveness, green processing and facile modular design make the boronic acid-tannic acid gels promising candidates for the development of smart soft materials.
- Nature polyphenols,
- Boronic acids,
- Hydrogels,
- Boronate-catechol complexation,
- All-small-molecule dynamic covalent gels
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