Citation: Wen Ying, Huo Fangjun, Yin Caixia. Organelle targetable fluorescent probes for hydrogen peroxide[J]. Chinese Chemical Letters, ;2019, 30(10): 1834-1842. doi: 10.1016/j.cclet.2019.07.006 shu

Organelle targetable fluorescent probes for hydrogen peroxide

Wen Ying ^a ,
Huo Fangjun ^b ,
Yin Caixia ^a,*,

a.
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
b.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China

yincx@sxu.edu.cn

Received Date: 9 May 2019
Revised Date: 1 July 2019
Accepted Date: 2 July 2019
Available Online: 3 October 2019

Figures(12)

Hydrogen peroxide (H₂O₂), as important products of oxygen metabolism, plays an important role in many biological processes, such as immune responses and cellular signal transduction. However, abnormal production of H₂O₂ can damage cellular biomolecules, which was closely associated with many diseases. Thus, it is urgent to monitor the level change of H₂O₂ in living cells, particularly at subcellular levels. Toward this end, a wide variety of H₂O₂ fluorescent probes have been designed, developed and applied for imaging of H₂O₂ in subcellular levels. In this review, we highlight the representative cases of H₂O₂ fluorescent probes with mitochondria, nuclei and lysosomes-targetable ability. The review contains organelle target strategies, structures, fluorescence behavior and biological applications of these probes.
- Hydrogen peroxide,
- Fluorescence probes,
- Mitochondria target,
- Nuclei target,
- Lysosomes target,
- Living cells
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