Citation: Shi Shibin, Yuan Kuo, Jia Yanxing. Seven-step total synthesis of α-cyclopiazonic acid[J]. Chinese Chemical Letters, ;2020, 31(2): 401-403. doi: 10.1016/j.cclet.2019.06.048 shu

Seven-step total synthesis of α-cyclopiazonic acid

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

yxjia@bjmu.edu.cn

Received Date: 12 May 2019
Revised Date: 18 June 2019
Accepted Date: 26 June 2019
Available Online: 27 June 2019

Figures(4)

A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole. Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulation to form the C/D rings.
- Indole alkaloids,
- Total synthesis,
- Cascade cyclization,
- Natural products
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