Citation: Chen Yuxuan, Li Bowen, Chen Xiaohong, Wu Min, Ji Yongtao, Tang Guping, Ping Yuan. A supramolecular co-delivery strategy for combined breast cancer treatment and metastasis prevention[J]. Chinese Chemical Letters, ;2020, 31(5): 1153-1158. doi: 10.1016/j.cclet.2019.06.022 shu

A supramolecular co-delivery strategy for combined breast cancer treatment and metastasis prevention

Chen Yuxuan ^a,1,2 ,
Li Bowen ^b,1 ,
Chen Xiaohong ^b ,
Wu Min ^a ,
Ji Yongtao ^c ,
Tang Guping ^a,*, ,
Ping Yuan ^b,*,

a.
Department of Chemistry, Zhejiang University, Hangzhou 310027, China
b.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
c.
School of Medicine, Zhejiang University, Hangzhou 310058, China

tangguping@zju.edu.cn

pingy@zju.edu.cn

Received Date: 28 April 2019
Revised Date: 3 June 2019
Accepted Date: 13 June 2019
Available Online: 13 June 2019

Figures(7)

We herein propose a co-delivery approach where small interference RNA (siRNA) and anticancer chemotherapeutic drug are simultaneously loaded into a single delivery carrier for the combined treatment of breast cancer and metastasis prevention. The co-delivery vector is composed of chondroitin sulfate (CS)-coated β-cyclodextrin-polyethylenemine polymer, which is capable of loading paclitaxel (PTX) and siRNA simultaneously to form therapeutic nanocomplexes. The nanocomplex, termed as CPPTX-siCD146-CS, is demonstrated to have strong active targeting ability towards CD44-overexpresing breast cancer cells. Moreover, the co-delivery of PTX and siRNA not only effectively inhibits cancer cells proliferation and induces apoptosis, but also well prevents metastasis. Importantly, CP-PTX-siCD146-CS nanocomplexes exhibit stronger cytotoxic effects and anti-metastatic effects on MBA-MD-231 breast cancer cells, in comparison with PTX or siCD146 mono-treatment. The current study defines a potential therapeutic strategy for the combined breast cancer treatment and metastasis prevention from a codelivery perspective.
- Nanoparticle,
- Drug delivery,
- siRNA,
- Chemotherapy,
- Supramolecular nanocomplex
1. [1]
  Cancer Genome Atlas Network, Nature 490(2012) 61-70. doi: 10.1038/nature11412
2. [2]
  D. Hanahan, R.A. Weinberg, Cell 144(2011) 574-646.
3. [3]
  W.D. Foulkes, I.E. Smith, J.S. Reis-Filho, N. Engl. J. Med. 363(2010) 1938-1948. doi: 10.1056/NEJMra1001389
4. [4]
  E.P. Mamounas, J. Bryant, B. Lembersky, et al., J. Clin. Oncol. 23(2005) 3686-3696. doi: 10.1200/JCO.2005.10.517
5. [5]
  R.A. Weinberg, C.L. Chaffer, Science 331(2011) 1559-1564. doi: 10.1126/science.1203543
6. [6]
  L. Carey, G. Winer, G. Viale, et al., Nat. Rev. Clin. Oncol. 7(2010) 683-692. doi: 10.1038/nrclinonc.2010.154
7. [7]
  L.R. Yates, S. Knappskog, D. Wedge, Cancer Cell 32(2017) 169-184. doi: 10.1016/j.ccell.2017.07.005
8. [8]
  M. Wu, X. Liu, W. Jin, et al., J. Control. Release 253(2017) 110-121. doi: 10.1016/j.jconrel.2017.03.011
9. [9]
  J. Wang, W. Xu, S. Li, et al., J. Biomed. Nanotechnol. 14(2018) 2102-2113. doi: 10.1166/jbn.2018.2624
10. [10]
  H. Xiao, L. Yan, E.M. Dempsey, et al., Prog. Polym. Sci. 87(2018) 70-106. doi: 10.1016/j.progpolymsci.2018.07.004
11. [11]
  Y. Zhang, R. Sha, L. Zhang, et al., Nat. Commun. 9(2018) 4236. doi: 10.1038/s41467-018-06529-y
12. [12]
  X. Feng, J. Ding, R. Gref, X. Chen, Chin. J. Polym. Sci. 35(2017) 693-699. doi: 10.1007/s10118-017-1932-7
13. [13]
  S. Tang, Q. Meng, H. Sun, Adv. Funct. Mater. 26(2016) 6033-6046. doi: 10.1002/adfm.201601703
14. [14]
  Y. Ping, C. Liu, Z. Zhang, et al., Biomaterials 32(2011) 8328-8341. doi: 10.1016/j.biomaterials.2011.07.038
15. [15]
  Y. Li, H. Bai, H. Wang, et al., Nanoscale 10(2018) 203-214. doi: 10.1039/C7NR06689A
16. [16]
  C.J. Cheng, R. Bahal, I.A. Babar, et al., Nature 518(2015) 107-110. doi: 10.1038/nature13905
17. [17]
  J. Zhou, Y. Wu, C. Wang, et al., Angew. Chem. Int. Ed. 55(2016) 1-6. doi: 10.1002/anie.201510990
18. [18]
  J. Nie, B. Qiao, S. Duan, et al., Adv. Mater. 1416(2018) 1801570.
19. [19]
  N. Afratis, C. Gialeli, D. Nikitovic, et al., FEBS J. 279(2012) 1177-1197. doi: 10.1111/j.1742-4658.2012.08529.x
20. [20]
  R.D. Prinz, C.M. Willis, A. Viloria-Petit, M. Kluppel, Genet. Mol. Res. 14(2011) 3901-3913.
21. [21]
  D.J. Silver, F.A. Siebzehnrubl, M.J. Schildts, et al., J. Neurosci. 33(2013) 15603-15617. doi: 10.1523/JNEUROSCI.3004-12.2013
22. [22]
  C.A. Cooney, F. Jousheghany, A. Yao-Borengasser, et al., Breast Cancer Res. 13(2011) R59. doi: 10.1186/bcr2896
23. [23]
  B. Monzavi-karbassi, J.S. Stanley, L. Hennings, et al., Int. J. Cancer 120(2016) 1179-1191.
24. [24]
  L. Zhao, M. Liu, J. Wang, et al., Carbohydr. Polym. 133(2015) 391-399. doi: 10.1016/j.carbpol.2015.07.063
25. [25]
  G. Kwak, D. Kim, G. Nam, et al., ACS Nano 11(2017) 10135-10146. doi: 10.1021/acsnano.7b04717
26. [26]
  H. Yan, O.P. Oommen, D. Yu, et al., Adv. Funct. Mater. 25(2015) 3907-3915. doi: 10.1002/adfm.201500695
27. [27]
  O.P. Varghese, J. Liu, K. Sundaram, J. Hilborn, O.P. Oommen, Biomater. Sci. 4(2016) 1310-1313. doi: 10.1039/C6BM00335D
28. [28]
  K. Liang, K.H. Bae, F. Lee, et al., J. Control. Release 226(2016) 205-216. doi: 10.1016/j.jconrel.2016.02.004
29. [29]
  T. Jiang, R. Mo, A. Bellotti, J. Zhou, Z. Gu, Adv. Funct. Mater. 24(2014) 2295-2304. doi: 10.1002/adfm.201303222
30. [30]
  Q. Zeng, W. Li, D. Lu, et al., Cell Commun. Signal 15(2017) 45. doi: 10.1186/s12964-017-0200-3
31. [31]
  V. Todorovic, G. Sersa, M. Cemazar, Cancer Gene Ther. 20(2013) 208-210. doi: 10.1038/cgt.2013.3
32. [32]
  T. Wan, D. Niu, C. Wu, et al., Mater. Today 12(2018) 003.
33. [33]
  Z. Zhang, T. Wan, Y. Chen, et al., Macromol. Rapid Commun. (2018) 1800068.
34. [34]
  D. Li, Y. Li, H. Xing, et al., Adv. Funct. Mater. 24(2014) 5482-5492. doi: 10.1002/adfm.201400456
35. [35]
  Y. Ping, Q. Hu, G. Tang, et al., Biomaterials 34(2013) 6482-6494. doi: 10.1016/j.biomaterials.2013.03.071
36. [36]
  X. Chen, Y. Qiu, C. Owh, X.J. Loh, Y. Wu, Nanoscale 8(2016) 18876-18881. doi: 10.1039/C6NR08055C
37. [37]
  G. Yu, Z. Yang, X. Fu, et al., Nat. Commun. 9(2018) 766. doi: 10.1038/s41467-018-03119-w
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9. [9]
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