Citation: Li Fengli, Sun Weiguang, Zhang Sitian, Gao Weixi, Lin Shuang, Yang Beiye, Chai Chenwei, Li Huaqiang, Wang Jianping, Hu Zhengxi, Zhang Yonghui. New cyclopiane diterpenes with antiinflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2[J]. Chinese Chemical Letters, ;2020, 31(1): 197-201. doi: 10.1016/j.cclet.2019.04.036 shu

New cyclopiane diterpenes with antiinflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

hzx616@126.com

zhangyh@mails.tjmu.edu.cn

Received Date: 20 March 2019
Revised Date: 15 April 2019
Accepted Date: 15 April 2019
Available Online: 17 January 2019

Figures(4)

Three new rare cyclopiane diterpenes (1-3), together with thirteen known compounds (4-16), were isolated and identified from a sea sediment-derived fungus Penicillium sp. TJ403-2. The planar and relative structures of compounds 1-3 were elucidated by HRESIMS, one- and two-dimensional NMR analyses, and their absolute configurations were further established by X-ray crystallography experiment. Compounds 1-3 were evaluated for the antiinflammatory activity against LPS-induced NO production, and compound 1 showed notable inhibitory potency with an IC₅₀ value of 2.19±0.25 μmol/L, which was three fold lower than the positive control indomethacin (IC₅₀=8.76±0.92 μmol/L). Further Western blot and immunofluorescence experiments demonstrated its mechanism of action to be that 1 inhibited the NF-ΚB-activated pathway, highlighting it as a promising starting point for the development of new antiinflammatory agents.
- Penicillium sp. TJ403-2,
- Cyclopiane diterpenes,
- Structural elucidation,
- antiinflammatory activity,
- NF-ΚB pathway
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