Citation: Xu Zeyu, Jiang Xingxing, Liu Shuping, Yang Minghui. Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination[J]. Chinese Chemical Letters, ;2020, 31(1): 185-188. doi: 10.1016/j.cclet.2019.04.026 shu

Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination

Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

yangminghui@csu.edu.cn

Received Date: 13 February 2019
Revised Date: 11 April 2019
Accepted Date: 11 April 2019
Available Online: 12 January 2019

Figures(4)

An electrochemical sensor for doxycycline hyclate (DC) detection with high sensitivity and good selectivity is reported. The sensor was fabricated by electro-polymerization of molecularly imprinted polymers (MIPs) in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs/GCE). The MWCNTs can significantly increase the current response of the sensor, leading to enhanced sensitivity. The MIPs provide selective recognition sites for DC detection. The experimental parameters, such as the polymer monomer concentration, supporting electrolyte pH, the time for electro-polymerization and the incubation time of the sensor with DC were optimized. Under optimized experimental conditions, the sensor displayed a linear range of 0.05 μmol/L-0.5 μmol/L towards DC detection, with the detection limit of 1.3×10^-2 μmol/L. The sensor was successfully applied for recovery test of DC in human serum samples.
- Electrochemical sensor,
- Doxcycline hyclate,
- Molecularly imprinted polymers,
- Multi-walled carbon nanotubes,
- Electro-polymerization
1. [1]
  E. Buduneli, S. Vardar-Sengül, N. Buduneli, et al., J. Periodont. 78(2007) 127-134. doi: 10.1902/jop.2007.050451
2. [2]
  M. Mishra, B. Mishra, Acta Pharm. Sin. B 2(2012) 518-526. doi: 10.1016/j.apsb.2012.05.001
3. [3]
  B. Sloan, N. Scheinfeld, Expert Opin. Drug Saf. 7(2008) 571-577. doi: 10.1517/14740338.7.5.571
4. [4]
  D. Vargas-Estrada, J. Gracia-Mora, H. Sumano, Res. Vet. Sci. 84(2008) 477-482. doi: 10.1016/j.rvsc.2007.07.003
5. [5]
  E. Ayaslioglu, E. Erkek, A. Oba, E. Cebecioglu, Aust. Dent. J. 50(2005) 273-275. doi: 10.1111/j.1834-7819.2005.tb00373.x
6. [6]
  F. Stickel, H.K. Seitz, J. Gastrointest. Liver Dis. 22(2013) 189-197.
7. [7]
  S. Thiele-Bruhn, J. Plant Nutr. Soil Sci. 166(2003) 145-167. doi: 10.1002/jpln.200390023
8. [8]
  A. Ito, T. Sato, M. Ota, et al., Antimicrob. Agents Chemother. 62(2018) 1-11.
9. [9]
  H. Ji, H. Sun, X. Qu, Adv. Drug Deliv. Rev. 105(2016) 176-189. doi: 10.1016/j.addr.2016.04.009
10. [10]
  E.Y. Klein, T.P. van Boeckel, E.M. Martinez, et al., Proc. Natl. Acad. Sci. U. S. A. 115(2018) 3463-3470. doi: 10.1073/pnas.1717295115
11. [11]
  E. Patyra, E. Kowalczyk, K. Kwiatek, Bull. Vet. Inst. Pulawy 56(2012) 329-333. doi: 10.2478/v10213-012-0058-5
12. [12]
  G. Islas, J.A. Rodriguez, I. Perez-Silva, J.M. Miranda, I.S. Ibarra, J. Anal. Methods Chem. 2018(2018) 1-7.
13. [13]
  J. Adrian, F. Ferna'ndez, F. Sa'nchez-Baeza, M.P. Marco, J. Agric. Food Chem. 60(2012) 3837-3846. doi: 10.1021/jf2053355
14. [14]
  X. Feng, J. Ashley, T. Zhou, Y. Sun, Microchim. Acta 185(2018) 500-508. doi: 10.1007/s00604-018-2999-8
15. [15]
  J. Tashkhourian, G. Absalan, M. Jafari, S. Zare, Spectroc. Acta A 152(2016) 119-125. doi: 10.1016/j.saa.2015.07.063
16. [16]
  K. Haupt, K. Mosbach, Chem. Rev. 100(2000) 2495-2504. doi: 10.1021/cr990099w
17. [17]
  M. Ulbricht, J. Chromatogr. B 804(2004) 113-125. doi: 10.1016/j.jchromb.2004.02.007
18. [18]
  P. Wang, X. Fu, J. Li, et al., Chin. Chem. Lett. 22(2011) 611-614. doi: 10.1016/j.cclet.2010.12.004
19. [19]
  S. Ansari, Trac-Trends Anal. Chem. 93(2017) 134-151. doi: 10.1016/j.trac.2017.05.015
20. [20]
  A.G. Mayes, Trac-Trends Anal. Chem. 16(1997) 321-332. doi: 10.1016/S0165-9936(97)00037-X
21. [21]
  J. Bai, X. Zhang, Y. Peng, et al., Sensor. Actuat. B-Chem. 238(2017) 420-426. doi: 10.1016/j.snb.2016.07.035
22. [22]
  L. Yang, B. Xu, H. Ye, F. Zhao, B. Zeng, Sensor. Actuat. B-Chem. 251(2017) 601-608. doi: 10.1016/j.snb.2017.04.006
23. [23]
  Z.Z. Yin, S.W. Cheng, L.B. Xu, et al., Biosens. Bioelectron. 100(2018) 565-570. doi: 10.1016/j.bios.2017.10.010
24. [24]
  H. Dai, D. Xiao, H. He, et al., Microchim. Acta 182(2014) 893-908.
25. [25]
  E. Roy, S. Patra, A. Tiwari, R. Madhuri, P.K. Sharma, Biosens. Bioelectron. 89(2017) 234-248. doi: 10.1016/j.bios.2016.02.056
26. [26]
  Y. Yin, L. Yan, Z. Zhang, J. Wang, Talanta 144(2015) 671-679. doi: 10.1016/j.talanta.2015.06.067
27. [27]
  R.H. Baughman, A.A. Zakhidov, W.A. de Heer, Science 297(2002) 787-792. doi: 10.1126/science.1060928
28. [28]
  R.J. Chen, Y. Zhang, D. Wang, H. Dai, J. Am. Chem. Soc. 123(2001) 3838-3839. doi: 10.1021/ja010172b
29. [29]
  H. Wang, S. Yao, Y. Liu, S. Wei, J. Su, G. Hu, Biosens. Bioelectron. 87(2017) 417-421. doi: 10.1016/j.bios.2016.08.092
30. [30]
  L. Zhang, Y. Wen, Y. Yao, et al., Chin. Chem. Lett. 25(2014) 517-522. doi: 10.1016/j.cclet.2013.12.020
31. [31]
  G. Yang, F. Zhao, B. Zeng, Biosens. Bioelectron. 53(2014) 447-452. doi: 10.1016/j.bios.2013.10.029
32. [32]
  F. Wang, L. Zhu, J. Zhang, Sensor. Actuat. B-Chem. 192(2014) 642-647. doi: 10.1016/j.snb.2013.11.037
1. [1]
  Ran Zhu , Pan Zhang , Yitong Xu , Jiutong Ma , Qiong Jia . Design of host-guest interaction based molecularly imprinted polymers: Targeting recognition of the epitope of neuron-specific enolase via a SERS assay. Chinese Chemical Letters, 2025, 36(6): 110259-. doi: 10.1016/j.cclet.2024.110259
2. [2]
  Xu Guo , Dandan Yang , Zhongyu He , Jie Ding , Lan Ding , Daqian Song . Construction of porous molecularly imprinted polymer on amylose for selective adsorption of estradiol. Chinese Chemical Letters, 2026, 37(5): 111927-. doi: 10.1016/j.cclet.2025.111927
3. [3]
  Jie Zhou , Chuanxiang Zhang , Changchun Hu , Shuo Li , Yuan Liu , Zhu Chen , Song Li , Hui Chen , Rokayya Sami , Yan Deng . Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg²⁺. Chinese Chemical Letters, 2024, 35(11): 109561-. doi: 10.1016/j.cclet.2024.109561
4. [4]
  Xiang Huang , Na Wang , Junyan Liu , Wang Sun , Guorong Sun , Zhou Zhang , Shun Lu , Yang Wang . Flexible hydrogels with in-situ grown cobalt-based metal-organic frameworks for high-performance electrochemical detection of 2,4,6-trichloropshenol. Chinese Chemical Letters, 2026, 37(6): 112067-. doi: 10.1016/j.cclet.2025.112067
5. [5]
  Dongshi Feng , Jiangdong Dai , Zhi Zhu , Pengwei Huo , Yongsheng Yan , Chunxiang Li . Molecularly imprinted electrochemical sensor arrays combined with machine learning for simultaneous determination of three neonicotinoid insecticides. Chinese Chemical Letters, 2026, 37(5): 111789-. doi: 10.1016/j.cclet.2025.111789
6. [6]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
7. [7]
  Shuangying Li , Qingxiang Zhou , Zhi Li , Menghua Liu , Yanhui Li . Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor. Chinese Chemical Letters, 2024, 35(5): 108693-. doi: 10.1016/j.cclet.2023.108693
8. [8]
  Sili Qing , Yuxi Xu , Shuai Gao , Li-Ping Jiang , Xiaoge Wu , Wenlei Zhu . An efficient and sustainable hybrid electrochemical system for heterogeneous electro-Fenton degradation of phenolic pollutants. Chinese Chemical Letters, 2026, 37(7): 112193-. doi: 10.1016/j.cclet.2025.112193
9. [9]
  Wei GUO , Zhuoyi GUO , Xiaoxin LI , Wei ZHANG , Juanzhi YAN , Tingting GUO . Electrochemical sensor based on a Co(Ⅱ)-based metal-organic framework for the detection of Cd²⁺ and Pb²⁺. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1889-1902. doi: 10.11862/CJIC.20250097
10. [10]
  Zhijuan Niu , Peizhe Sun , Kwangnak Koh , Changping Li . Ultrasensitive electrochemical sensor based on para-sulfonatocalix[4]arene functionalized gold nanoparticles for sulfamethazine detection. Chinese Chemical Letters, 2025, 36(11): 110844-. doi: 10.1016/j.cclet.2025.110844
11. [11]
  Xue Zhao , Mengshan Chen , Dan Wang , Haoran Zhang , Guangzhi Hu , Yingtang Zhou . Ultrafine nano-copper derived from dopamine polymerization & synchronous adsorption achieve electrochemical purification of nitrate to ammonia in complex water environments. Chinese Chemical Letters, 2024, 35(8): 109327-. doi: 10.1016/j.cclet.2023.109327
12. [12]
  Fan LIU , Xiaoli CHEN , Jing REN , Yantao LEI , Huali CUI , Hua YANG , Jijiang WANG . Highly sensitive and multi-response Zn-MOF fluorescence sensor: Design, synthesis, and detection of 4-nitrophenol, Cu²⁺, and pyrimethanil. Chinese Journal of Inorganic Chemistry, 2026, 42(4): 872-882. doi: 10.11862/CJIC.20250287
13. [13]
  Man Xu , Qianyi Li , Jingyao Ma , Hao Li , Yunfei Zhu , Fan Yu , Kuande Wang , Tao Zhou , Quanyou Feng , Linghai Xie , Jinyi Lin . Wide bandgap steric carbazole-fluorene-nanogrid polymers via metal-free CN polymerization for deep-blue polymer light-emitting diodes. Chinese Chemical Letters, 2026, 37(1): 111551-. doi: 10.1016/j.cclet.2025.111551
14. [14]
  Wei-Jia Wang , Kaihong Chen . Molecular-based porous polymers with precise sites for photoreduction of carbon dioxide. Chinese Chemical Letters, 2025, 36(1): 109998-. doi: 10.1016/j.cclet.2024.109998
15. [15]
  Li Li , Lin-Lin Zhang , Yansha Gao , Lu-Ying Duan , Wuying Yang , Xigen Huang , Yanping Hong , Jiaxin Hong , Lin Yuan , Limin Lu . Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin. Chinese Chemical Letters, 2025, 36(7): 110436-. doi: 10.1016/j.cclet.2024.110436
16. [16]
  Zeyu XU , Tongzhou LU , Haibo SHAO , Jianming WANG . Preparation and electrochemical lithium storage performance of porous silicon microsphere composite with metal modification and carbon coating. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1995-2008. doi: 10.11862/CJIC.20240164
17. [17]
  Yi Liu , Peng Lei , Yang Feng , Shiwei Fu , Xiaoqing Liu , Siqi Zhang , Bin Tu , Chen Chen , Yifan Li , Lei Wang , Qing-Dao Zeng . Topologically engineering of π-conjugated macrocycles: Tunable emission and photochemical reaction toward multi-cyclic polymers. Chinese Chemical Letters, 2024, 35(10): 109571-. doi: 10.1016/j.cclet.2024.109571
18. [18]
  Xinyu Wu , Jianfeng Lu , Zihao Zhu , Suijun Liu , Herui Wen . Recent advances of metal-organic frameworks and MOF-derived materials based on p-block metal for the electrochemical reduction of carbon dioxide. Chinese Chemical Letters, 2025, 36(7): 110151-. doi: 10.1016/j.cclet.2024.110151
19. [19]
  Menglin Zhou , Lin Zhang , Xuefei Shan , Fengqin Chang , Wentong Chen , Xuguang An , Guangzhi Hu . Hydrangea-like B/N co-doped carbon-based electrochemical sensors for the efficient and sensitive detection of aristolochic acid in Aristolochia. Chinese Chemical Letters, 2025, 36(12): 111073-. doi: 10.1016/j.cclet.2025.111073
20. [20]
  Yihan Fu , Xinyi Wang , Sen Li , Weifeng Lin , Mingjie Liu . Molecularly-engineered zwitterionic micelles for adaptive lubrication. Chinese Chemical Letters, 2026, 37(6): 111991-. doi: 10.1016/j.cclet.2025.111991

Get Citation

PDF

XML

Metrics

PDF Downloads(16)
Abstract views(2143)
HTML views(106)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142