Citation: Liu Guo-Kai, Li Xin, Qin Wen-Bing, Lin Wei-Feng, Lin Li-Ting, Chen Jia-Yi, Liu Jian-Jian. Selective O-difluoromethylation of 1, 3-diones using S-(difluoromethyl) sulfonium salt[J]. Chinese Chemical Letters, ;2019, 30(8): 1515-1518. doi: 10.1016/j.cclet.2019.03.036 shu

Selective O-difluoromethylation of 1, 3-diones using S-(difluoromethyl) sulfonium salt

School of Pharmaceutical Sciences, Shenzhen University Health Science Centre, Shenzhen University, Shenzhen 518060, China

gkliu@szu.edu.cn

Received Date: 22 February 2019
Revised Date: 15 March 2019
Accepted Date: 18 March 2019
Available Online: 23 August 2019

Figures(4)

A facile and highly efficient approach for selective O-difluoromethylation of 1, 3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described. And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions. Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway.
- Difluorocarbene,
- Difluoromethyl enol ethers,
- 1, 3-Diones,
- O-Difluoromethylation,
- S-(Difluoromethy)sulfonium salt
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