Citation: Sun Shang-Zheng, Xu Hui, Dai Hui-Xiong. Copper-catalyzed α-selective C-H trifluoromethylation of acrylamides with TMSCF₃[J]. Chinese Chemical Letters, ;2019, 30(5): 969-972. doi: 10.1016/j.cclet.2019.02.011 shu

Copper-catalyzed α-selective C-H trifluoromethylation of acrylamides with TMSCF₃

a.
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
b.
Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China

hxdai@simm.ac.cn

Received Date: 22 December 2018
Revised Date: 22 January 2019
Accepted Date: 19 February 2019
Available Online: 19 May 2019

Figures(5)

A copper-catalyzed α-selective C-H trifluoromethylation of acrylamides with TMSCF₃ is described. A wide range of arenes and heteroarenes at the β-position of acrylamides are compatible with the reaction, affording the corresponding (E)-trifluoromethylated products in moderate to good yields. The reaction proceeded fast and can be completed within 30 min.
- α-Selectivity,
- C-H trifluoromethylation,
- Copper,
- Acrylamides,
- Heterocycle
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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Copper-catalyzed α-selective C-H trifluoromethylation of acrylamides with TMSCF3

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通讯作者: 陈斌, bchen63@163.com

Copper-catalyzed α-selective C-H trifluoromethylation of acrylamides with TMSCF₃