Citation: Wang Ting, Deng Yu, Qu Guanwen, Chen Yaozhong, Shang Jing, Feng Zhangqi, Zheng Jie, Yang Fengyu, He Nongyue. Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3[J]. Chinese Chemical Letters, ;2019, 30(5): 1043-1050. doi: 10.1016/j.cclet.2019.01.011 shu

Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3

Wang Ting ^a,b,f,*, ,
Deng Yu ^a,f ,
Qu Guanwen ^a,b,f ,
Chen Yaozhong ^a,f ,
Shang Jing ^c ,
Feng Zhangqi ^b,d,f ,
Zheng Jie ^b,e ,
Yang Fengyu ^b,e ,
He Nongyue ^a,f,*,

a.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, South east University, Nanjing 210096, China
b.
Department of Chemical and Biomolecular Engineering, The University of Akron, Akron OH 44325, United States
c.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
d.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
e.
Nanjing Daniel New Mstar Technology Ltd., Nanjing 211200, China
f.
National Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, Nanjing 210096, China

tingwang@seu.edu.cn

nyhe1958@163.com

Received Date: 30 November 2018
Revised Date: 8 January 2019
Accepted Date: 11 January 2019
Available Online: 11 May 2019

Figures(6)

Breast cancer is one of the most common cancers in the world, survival rates of breast cancer are rising as screening and treatment improve. Many new technologies applied in the biomedical domain have been born for rapid diagnosis and treatment. In this work, visualization cell microarray chip with three dimensional (3D) embedded cell scaffold for cell diagnosis and treatment was designed. DNA segment, targeting on breast cancer cells SK-BR-3, were modified with camptothecin and used as model drug. Cell microarray chip system successfully control the diffusion of small molecules and locally introduced the compounds into cells. 3D embedded cell scaffold in the cell array chip afforded an environment with continuous medium supplementary and help controlling the diffusion of small molecules drugs. By cell microarray chip system, SK-BR-3 was targeted screening and killing in one step. Cell microarray chip system can achieve accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3 and have a potential to develop to be an effective and accurate drug screen method for evaluating the drug effect of the booming chemicals.
- Cell micro-array chip,
- DNA segment,
- Target,
- SK-BR-3,
- Camptothecin
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