Citation: Tao Chun, Yu Yue, Chen Zhenzhen, Zhang Minxin, Liu Linlin, Liu Zhihong, Zhang Jialiang, Zhang Qian, Song Hongtao. Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system[J]. Chinese Chemical Letters, ;2018, 29(12): 1849-1852. doi: 10.1016/j.cclet.2018.11.022 shu

Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system

Tao Chun ^a,1 ,
Yu Yue ^a,b,1 ,
Chen Zhenzhen ^a,b ,
Zhang Minxin ^a ,
Liu Linlin ^a ,
Liu Zhihong ^a ,
Zhang Jialiang ^a ,
Zhang Qian ^b,* ,
Song Hongtao ^a,*

a.
Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University(Fuzhou General Hospital), Fuzhou 350025, China
b.
College of Pharmacy, Fujian Medical University, Fuzhou 350108, China

pixiaprivate@126.com

sohoto@vip.163.com

Received Date: 10 October 2018
Revised Date: 7 November 2018
Accepted Date: 12 November 2018
Available Online: 20 December 2018

Figures(4)

To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system (SMEDDS), mesoporous silica nanospheres (MSNs) and Santa Barbara Amorphous-15 (SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 ±5.82 nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2312.19 ±106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus (SRL). However, MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62%. Thus, the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs.
- Mesopores,
- Mesoporous silica nanospheres,
- SBA-15,
- Self-microemulsifying drug delivery system,
- Sirolimus,
- Bioavailability
1. [1]
  A. Maleki, H. Kettiger, A. Schoubben, et al., J. Control. Release 262(2017) 329-347. doi: 10.1016/j.jconrel.2017.07.047
2. [2]
  P. Kumar, P. Tambe, K.M. Paknikar, V. Gajbhiye, J. Control. Release 287(2018) 35-57. doi: 10.1016/j.jconrel.2018.08.024
3. [3]
  Y. Zhou, G. Quan, Q. Wu, et al., Acta Pharm. Sin. B 8(2018) 165-177. doi: 10.1016/j.apsb.2018.01.007
4. [4]
  K.K. Qian, R.H. Bogner, J. Pharm. Sci. 101(2012) 444-463. doi: 10.1002/jps.22779
5. [5]
  R.J. Ahern, J.P. Hanrahan, J.M. Tobin, et al., Eur. J. Pharm. Sci. 50(2013) 400-409. doi: 10.1016/j.ejps.2013.08.026
6. [6]
  T. Limnell, H.A. Santos, E. Makila, et al., J. Pharm. Sci. 100(2011) 3294-3306. doi: 10.1002/jps.22577
7. [7]
  M. Van Speybroeck, R. Mols, R. Mellaerts, et al., Eur. J. Pharm. Biopharm. 75(2010) 354-365. doi: 10.1016/j.ejpb.2010.04.009
8. [8]
  M. Vialpando, S. Smulders, S. Bone, et al., J. Pharm. Sci. 105(2016) 2782-2793. doi: 10.1016/j.xphs.2016.03.003
9. [9]
  S. Pattnaik, K. Pathak, Curr. Pharm. Des. 23(2017) 467-480.
10. [10]
  M. Kazi, R. Al Amri, F.K. Alanazi, M.D. Hussain, Curr. Drug Deliv. 15(2018) 918-929. doi: 10.2174/1567201815666180116090910
11. [11]
  A. Khattab, L. Hassanin, N. Zaki, AAPS PharmSciTech 18(2017) 1657-1672. doi: 10.1208/s12249-016-0632-x
12. [12]
  W. Wu, Y. Wang, L. Que, Eur. J. Pharm. Biopharm. 63(2006) 288-294. doi: 10.1016/j.ejpb.2005.12.005
13. [13]
  S. Dokania, A.K. Joshi, Drug Deliv. 22(2015) 675-690. doi: 10.3109/10717544.2014.896058
14. [14]
  V. Pandey, S. Kohli, Crit. Rev. Ther. Drug Carrier Syst. 35(2018) 99-155. doi: 10.1615/CritRevTherDrugCarrierSyst.v35.i2
15. [15]
  D.J. Hauss, Adv. Drug Deliv. Rev. 59(2007) 667-676. doi: 10.1016/j.addr.2007.05.006
16. [16]
  C.J. Porter, C.W. Pouton, J.F. Cuine, W.N. Charman, Adv. Drug Deliv. Rev. 60(2008) 673-691. doi: 10.1016/j.addr.2007.10.014
17. [17]
  F. Li, R. Hu, B. Wang, et al., Acta Pharm. Sin. B 7(2017) 353-360. doi: 10.1016/j.apsb.2017.02.002
18. [18]
  Y. Sunazuka, K. Ueda, K. Higashi, et al., Int. J. Pharm. 546(2018) 263-271. doi: 10.1016/j.ijpharm.2018.05.031
19. [19]
  X. Xue, M. Cao, L. Ren, et al., AAPS PharmSciTech 19(2018) 1847-1859. doi: 10.1208/s12249-018-0991-6
20. [20]
  S. Kamboj, V. Rana, Int. J. Pharm. 501(2016) 311-325. doi: 10.1016/j.ijpharm.2016.02.008
21. [21]
  Y. Lei, Y. Lu, J. Qi, et al., Int. J. Nanomed. 6(2011) 795-805.
22. [22]
  L.A.D. Silva, S.L. Almeida, E.C.P. Alonso, et al., Int. J. Pharm. 541(2018) 1-10. doi: 10.1016/j.ijpharm.2018.02.020
23. [23]
  N.T. Tung, C.S. Tran, T.M. Pham, et al., Int. J. Pharm. 537(2018) 9-21. doi: 10.1016/j.ijpharm.2017.12.027
24. [24]
  R.B. Chavan, S.R. Modi, A.K. Bansal, Int. J. Pharm. 495(2015) 374-384. doi: 10.1016/j.ijpharm.2015.09.011
25. [25]
  K. Midha, M. Nagpal, G. Singh, G. Aggarwal, Curr. Drug Deliv. 14(2017) 1078-1096.
26. [26]
  R. Narayan, U.Y. Nayak, A.M. Raichur, S. Garg, Pharmaceutics 10(2018) 118. doi: 10.3390/pharmaceutics10030118
27. [27]
  D. Zhao, J. Feng, Q. Huo, et al., Science 279(1998) 548-552. doi: 10.1126/science.279.5350.548
28. [28]
  P.T. Tanev, T.J. Pinnavaia, Science 267(1995) 865-867. doi: 10.1126/science.267.5199.865
29. [29]
  X. Hu, C. Lin, D. Chen, et al., Int. J. Pharm. 438(2012) 123-133. doi: 10.1016/j.ijpharm.2012.07.055
30. [30]
  D. Wang, J. Huang, X. Wang, et al., Biomaterials 34(2013) 7662-7673. doi: 10.1016/j.biomaterials.2013.06.042
31. [31]
  J.J. Zimmerman, G.M. Ferron, H.K. Lim, V. Parker, J. Clin. Pharmacol. 39(1999) 1155-1161.
32. [32]
  F. Baxevanis, J. Kuiper, N. Fotaki, Eur. J. Pharm. Biopharm. 107(2016) 234-248. doi: 10.1016/j.ejpb.2016.07.013
33. [33]
  S.G. Gumaste, A.T.M. Serajuddin, Eur. J. Pharm. Sci. 110(2017) 134-147. doi: 10.1016/j.ejps.2017.05.014
34. [34]
  J. Hu, T.L. Rogers, J. Brown, et al., Pharm. Res. 19(2002) 1278-1284. doi: 10.1023/A:1020390422785
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