Citation: He Haihong, He Tingting, Zhang Ziqian, Xu Xiu, Yang Huibin, Qian Xuhong, Yang Youjun. Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor[J]. Chinese Chemical Letters, ;2018, 29(10): 1497-1499. doi: 10.1016/j.cclet.2018.08.019 shu

Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor

He Haihong ^b ,
He Tingting ^b ,
Zhang Ziqian ^c ,
Xu Xiu ^b ,
Yang Huibin ^d ,
Qian Xuhong ^a,b ,
Yang Youjun ^a,b,,

a.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
b.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
c.
Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
d.
State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R & D Co., Ltd., Shenyang 110021, China

Corresponding author: Yang Youjun, youjunyang@ecust.edu.cn
Received Date: 6 August 2018
Revised Date: 30 August 2018
Accepted Date: 30 August 2018
Available Online: 1 October 2018

Figures(6)

Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).
- NO donor,
- Photo-trigger,
- Photo-calibrate,
- Platelet aggregation inhibition,
- Antimicrobial
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