Citation: Li Xuedong, Chen Bo, Lan Ling, Wang Ruili, Luo Duqiang, Liu Li, Cheng Liang. Selective recognition of HIV RNA by dinuclear metallic ligands[J]. Chinese Chemical Letters, ;2018, 29(11): 1637-1640. doi: 10.1016/j.cclet.2018.06.003 shu

Selective recognition of HIV RNA by dinuclear metallic ligands

Li Xuedong ^a,c ,
Chen Bo ^b ,
Lan Ling ^a,c ,
Wang Ruili ^a,c ,
Luo Duqiang ^b ,
Liu Li ^a,c ,
Cheng Liang ^a,c,*,,

a.
Beijing National Laboratory for Molecular Sciences(BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Cheng Liang, chengl@iccas.ac.cn

Received Date: 19 April 2018
Revised Date: 31 May 2018
Accepted Date: 1 June 2018
Available Online: 4 November 2018

Figures(5)

We describe the development of dinuclear metallic ligands to target specific HIV RNA structures. Two series of dipyridinyl-N bridged dinuclear metal complexes were synthesized in moderate to good yields and their binding activities toward TAR and RRE RNA were studied both experimentally and theoretically. The docking calculation elucidated some structure features in dimetallic complexes that can affect TAR RNA-binding properties.
- HIV RNA,
- Dinuclear metallic ligands,
- Binding,
- Molecular recognition,
- Selectivity
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