Citation: Jiang Yang, Long Hongyi, Zhu Yujie, Zeng Yi. Macrocyclic peptides as regulators of protein-protein interactions[J]. Chinese Chemical Letters, ;2018, 29(7): 1067-1073. doi: 10.1016/j.cclet.2018.05.028 shu

Macrocyclic peptides as regulators of protein-protein interactions

Jiang Yang ^a,, ,
Long Hongyi ^a ,
Zhu Yujie ^a ,
Zeng Yi ^b

a.
College of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China
b.
School of Science, Xihua University, Chengdu 610039, China

Corresponding author: Jiang Yang, jiangyang@cdu.edu.cn
Received Date: 15 April 2018
Revised Date: 7 May 2018
Accepted Date: 8 May 2018
Available Online: 26 July 2018

Figures(4)

Protein-protein interactions (PPIs) are recognized as attractive therapeutic targets. However targeting PPIs especially intracellular ones has been proven extremely difficult for conventional drug-like small molecules, and biological drugs such as monoclonal antibodies have difficulty in reaching intracellular targets. Macrocyclic peptides are promising candidates of PPI regulators for their potential in combining high potency and biological stability together. Cell permeability of macrocyclic peptides may also be achieved by structural modifications or conjugation to a cell-penetrating sequence. Significant progress has been made in this research area in recent years. Important technology progress and recent examples of macrocyclic peptide PPI modulators are reviewed.
- Macrocycle,
- Macrocyclic peptide,
- Protein-protein interaction,
- Inhibitor,
- Cell-penetrating peptide
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