Citation: Li Yaohao, Clark Kimberly A., Tan Zhongping. Methods for engineering therapeutic peptides[J]. Chinese Chemical Letters, ;2018, 29(7): 1074-1078. doi: 10.1016/j.cclet.2018.05.027 shu

Methods for engineering therapeutic peptides

Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder CO 80303, United States

Corresponding author: Tan Zhongping, zhongping.tan@colorado.edu
Received Date: 23 April 2018
Revised Date: 3 May 2018
Accepted Date: 8 May 2018
Available Online: 17 July 2018

Figures(5)

Peptides are a class of drugs that have become increasingly important and influential for the treatment of many human diseases. Compared to traditional small molecule drugs, peptides have the potential for higher target specificity and potency, along with better safety profiles. On the other hand, the complex and fragile nature of peptides poses significant challenges for their administration. Of particular concern is that they are often unstable and can be rapidly degraded by various proteases after dosing. To address these inherent problems of peptides, many different methods have been attempted. Here, we briefly review these methods, with an emphasis on the effect of each method.
- Therapeutic peptides,
- Engineering,
- Half-life,
- Stability,
- Solubility,
- Aggregation,
- Permeability
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