Citation: Xu Silin, Zhao Zhenguang, Zhao Junfeng. Recent advances in enzyme-mediated peptide ligation[J]. Chinese Chemical Letters, ;2018, 29(7): 1009-1016. doi: 10.1016/j.cclet.2018.05.024 shu

Recent advances in enzyme-mediated peptide ligation

Xu Silin ^a,1 ,
Zhao Zhenguang ^b,1 ,
Zhao Junfeng ^a,c,,

a.
Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China
b.
The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
c.
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Author Bio:

Junfeng Zhao Obtained his M.Sc. degree at Central China Normal University in 2005 with Prof. Mingwu Ding. He then pursued his Ph.D. study with Prof. Liuzhu Gong at Chengdu Institute of Organic Chemistry and finally got his Ph.D. degree at Nanyang Technological University in 2010 with Prof. Teckpeng Loh. After postdoctoral research at Nanyang Technological University with Prof. Chuanfa Liu, at University of Bonn with Prof. Michael Famulok, and at University of Münster with Prof. Armido Studer from 2010 to 2013, Junfeng moved to The University of Hong Kong, where he was a research assistant professor with Prof. Dan Yang. In 2014 he started his independent career at Jiangxi Normal University as a professor. Currently, his research interest focuses on the development of novel synthetic methodologies and chemical biology of peptides and proteins
Corresponding author: Zhao Junfeng, zhaojf@jxnu.edu.cn

Received Date: 4 April 2018
Revised Date: 2 May 2018
Accepted Date: 4 May 2018
Available Online: 22 July 2018

Figures(10)

Artificial synthesis and site-specific modification of peptides and proteins has evolved into an indispensable tool for protein engineers and chemical biologists. Chemical and enzymatic approaches to peptide ligation are important alternatives of recombinant DNA technology for protein synthesis and modification. Although as old as that of chemical procedures, enzyme-mediated peptide ligation is far less developed than that of chemical counterpart due to the difficult availability of peptide ligase. Fortunately, this situation has been changed slowly with the fast development of biological techniques. In the past decades, several natural peptide ligases have been discovered. Protein engineering to improve the ligation efficiencies of the natural peptide ligase and to reverse the functionality of protease provide more powerful peptide ligases. In this review, the advances of enzyme-mediated peptide ligation and their application in protein synthesis and modification will be discussed.
- Ligase,
- Peptide synthesis,
- Protein engineering,
- Enzyme-mediated peptide ligation,
- Site-specific protein modification
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沈阳化工大学材料科学与工程学院沈阳 110142