Citation: Guo Xiao-Qi, Liang Jun, Li Ying, Zhang Yong, Huang Dongliang, Tian Changlin. Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation[J]. Chinese Chemical Letters, ;2018, 29(7): 1139-1142. doi: 10.1016/j.cclet.2018.05.005 shu

Total synthesis of snake toxin α-bungarotoxin and its analogues by hydrazide-based native chemical ligation

Guo Xiao-Qi ^a,b ,
Liang Jun ^b ,
Li Ying ^c ,
Zhang Yong ^b ,
Huang Dongliang ^a ,
Tian Changlin ^a,b,,

a.
High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, China
b.
School of Life Science, University of Science and Technology of China, Hefei 230027, China
c.
Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

Corresponding author: Tian Changlin, cltian@ustc.edu.cn
Received Date: 31 March 2018
Revised Date: 19 April 2018
Accepted Date: 2 May 2018
Available Online: 3 July 2018

Figures(4)

Nicotinic acetylcholine receptors (nAChRs) play important roles in intercellular communications of nerve cells. α-Bungarotoxins (αBtx) is a moderator for the nAChRs. Chemical synthesis provides a promising way to access αBtx and their analogues. Here, we reported a new method for α-bungarotoxin by combining Fmoc-SPPS and peptide hydrazide based ligation strategy. The two-segment ligation method may enable efficient synthesis of αBtx analogues. These synthetic toxin peptides are useful tools for development of imaging or therapeutic reagents.
- Chemical synthesis,
- Native chemical ligation,
- Peptide hydrazide,
- α-Bungarotoxin,
- Nicotinic acetylcholine receptors
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