Citation: Qin Wenjing, Xu Chenchen, Zhao Yanfei, Yu Changmin, Shen Sheng, Li Lin, Huang Wei. Recent progress in small molecule fluorescent probes for nitroreductase[J]. Chinese Chemical Letters, ;2018, 29(10): 1451-1455. doi: 10.1016/j.cclet.2018.04.007 shu

Recent progress in small molecule fluorescent probes for nitroreductase

Qin Wenjing ^a ,
Xu Chenchen ^a ,
Zhao Yanfei ^a ,
Yu Changmin ^a,, ,
Shen Sheng ^b ,
Li Lin ^a,, ,
Huang Wei ^a

a.
Key Laboratory of Flexible Electronics(KLOFE) & Institute of Advanced Materials(IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM), Nanjing Tech University(NanjingTech), Nanjing 211816, China
b.
Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, China

Author Bio:

Prof. Dr. Changmin Yu received his PhD degree from South China University of Technology in 2013 and pursued postdoctoral studies in Chemistry at National University of Singapore from 2014 to 2015. He is currently a professor in Institute of Advanced Materials (IAM), Nanjing Tech University. His research interests include the functionalization of nanoparticles and their application in fluorescent detection, as well as in gene delivery

Prof. Dr. Lin Li earned his PhD (Chemistry, 2004–2009) from Anhui University. After getting his PhD degree, he obtained postdoctoral training as a research fellow in National University of Singapore (Chemical Biology, 2009–2015) in Prof. Shao Qin YAO's lab. In 2015, Dr. Li got his current professor position in Institute of Advanced Materials (IAM), Nanjing Tech University as a member of "Thousand Young Talents Program of China". His research group mainly focuses on the synthetic small-molecule indicators for detecting/inhibiting proteins in neurological disease. He has published over 80 papers in this area
Corresponding author: Yu Changmin, iamcmyu@njtech.edu.cn Li Lin, iamlli@njtech.edu.cn
Received Date: 21 February 2018
Revised Date: 2 April 2018
Accepted Date: 3 April 2018
Available Online: 4 October 2018

Figures(9)

Nitroreductase (NTR) is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia, which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply, can result in NTR overexpression. Using either nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH) as a source of reducing equivalents, NTR can catalyze the reduction of nitroaromatic compounds to the corresponding amines. Based on this reduction mechanism, NTR can be applied not only in the bioremediation and degradation of organic nitrogen compounds, but also in the development of NTR-targeted fluorescent probes to detect the hypoxic status of cancer cells. This review aims to provide a summary of the progress in fluorescent probes for NTR in recent years and elucidate the main fluorescent mechanisms that have been applied to design probes.
- Probe,
- Fluorescence,
- Nitroreductase,
- Small molecule probes
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