Citation: Yang Huan, Liang Hongjuan, Xie Yuwen, Chen Qiuyun. A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH₃O-PEG-phosphatide[J]. Chinese Chemical Letters, ;2018, 29(10): 1528-1532. doi: 10.1016/j.cclet.2018.02.011 shu

A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH₃O-PEG-phosphatide

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China

Corresponding author: Chen Qiuyun, chenqy@ujs.edu.cn
Received Date: 21 December 2017
Revised Date: 4 February 2018
Accepted Date: 24 February 2018
Available Online: 2 October 2018

Figures(8)

Cancer activated protein-inorganic nanoparticles can be cancer targeting turn-on imaging and therapy agents. Although various techniques were successfully employed for development of hybrid proteininorganic nanoparticles, cancer cell activated protein-inorganic nanoparticles have been challengeable. Herein, a cancer cell responsive nanoparticle (PDAMn-CuS@BSA-FA, NPs) was constructed and characterized. It is found that the quenching interaction of dyes (PDA) and central metal in NPs can be adjusted by CH₃O-PEG-phosphatide or the cancer cells, hence, NPs showed turn-on fluorescence emission with the titration of CH₃O-PEG-phosphatide. In particular, breast cancer cells lysis can switch on the green emission greatly, while normal cells show less effect. Breast cancer cells turn-on fluorescence imaging and mitochondria targeting imaging demonstrate that the NPs can sense breast cancer cells and enter mitochondria. Therefore, NPs can be both breast cancer targeting nanosensor.
- Activable sensor,
- Protein-inorganic nanoparticle,
- Cancer,
- CH₃O-PEG-phosphatide,
- Attenuator
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沈阳化工大学材料科学与工程学院沈阳 110142

A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH3O-PEG-phosphatide

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通讯作者: 陈斌, bchen63@163.com

A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH₃O-PEG-phosphatide