Citation: Fang Ge-Min, Chen Xiao-Xu, Yang Qian-Qian, Zhu Liang-Jing, Li Ning-Ning, Yu Hai-Zhu, Meng Xiang-Ming. Discovery, structure, and chemical synthesis of disulfide-rich peptide toxins and their analogs[J]. Chinese Chemical Letters, ;2018, 29(7): 1033-1042. doi: 10.1016/j.cclet.2018.02.002 shu

Discovery, structure, and chemical synthesis of disulfide-rich peptide toxins and their analogs

a.
Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, China
b.
Department of Chemistry, Anhui University, Hefei 230601, China

Corresponding author: Fang Ge-Min, fgmsxy@gmail.com Meng Xiang-Ming, mengxm@ahu.edu.cn
Received Date: 28 November 2017
Revised Date: 22 January 2018
Accepted Date: 25 January 2018
Available Online: 5 July 2018

Figures(11)

Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood of being drugs, when compared with traditional small molecules. Due to the great variety in molecule structures and the diverse biological functions, disulfide-rich peptide toxins have become a shining molecular library for the development of polypeptide drugs. In view of the increasing amount of related publications, here we summarize the discovery, structural elucidation and chemical synthesis of disulfide-rich peptide toxins and their analogs.
- Peptide toxins,
- Conotoxins,
- Cyclotides,
- Disulfide mimics,
- Chemical synthesis
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