Citation: Zhang Hao, Han Mengting, Yang Chenggen, Yu Lei, Xu Qing. Gram-scale preparation of dialkylideneacetones through Ca(OH)₂-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH[J]. Chinese Chemical Letters, ;2019, 30(1): 263-265. doi: 10.1016/j.cclet.2018.01.035 shu

Gram-scale preparation of dialkylideneacetones through Ca(OH)₂-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH

Zhang Hao ^a,b ,
Han Mengting ^b ,
Yang Chenggen ^b ,
Yu Lei ^a,b,*,, ,
Xu Qing ^b,*,,

a.
Guangling College, Yangzhou University, Yangzhou 225002, China
b.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Corresponding author: Yu Lei, yulei@yzu.edu.cn; yzuyulei@163.com Xu Qing, qing-xu@yzu.edu.cn; xuqing@yzu.edu.cn

Received Date: 30 November 2017
Revised Date: 9 January 2018
Accepted Date: 19 January 2018
Available Online: 31 January 2018

Figures(3)

A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)₂ as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v) as the green and safe solvent. The procedure was easily operated:In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level.
- Claisen-Schmidt condensation,
- Acetone,
- Aldehyde,
- α, β-Unsaturated ketone,
- Dialkylideneacetone
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Gram-scale preparation of dialkylideneacetones through Ca(OH)2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH

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通讯作者: 陈斌, bchen63@163.com

Gram-scale preparation of dialkylideneacetones through Ca(OH)₂-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH