Citation: Meng Lingjie, Guo Qinglan, Chen Minghua, Jiang Jiandong, Li Yuhuan, Shi Jiangong. Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots[J]. Chinese Chemical Letters, ;2018, 29(8): 1257-1260. doi: 10.1016/j.cclet.2017.12.001 shu

Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Shi Jiangong, shijg@imm.ac.cn
Received Date: 2 October 2017
Revised Date: 30 November 2017
Accepted Date: 1 December 2017
Available Online: 6 August 2017

Figures(6)

A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A (1), was isolated from an aqueous extract of the Isatis indigotica roots "ban lan gen". Its structure was elucidated by comprehensive analysis of spectroscopic data, including J- and NOESY correlation-based configurational analysis, circular dichroism (CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated.
- Isatis indigotica,
- Cruciferae,
- Ban lan gen,
- Indole-lignan conjugate,
- Isatindolignanoside A,
- Antiviral activity
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