Citation: Li Huibo, Chen Changmai, An Qin, Huo Guoyan, Run Mingtao. Photo-responsive nanoparticles for β-lapachone delivery in vitro[J]. Chinese Chemical Letters, ;2018, 29(9): 1347-1349. doi: 10.1016/j.cclet.2017.11.025 shu

Photo-responsive nanoparticles for β-lapachone delivery in vitro

Li Huibo ^a ,
Chen Changmai ^b ,
An Qin ^a ,
Huo Guoyan ^a,, ,
Run Mingtao ^a

a.
School of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
b.
State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Huo Guoyan, huoguoyan@yahoo.com
Received Date: 30 August 2017
Revised Date: 29 September 2017
Accepted Date: 16 November 2017
Available Online: 20 September 2017

Figures(4)

Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly (ethylene glycol) dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.
- Photoresponsive,
- Nanoparticle,
- β-Lapachone,
- UV irradiation,
- Treatment of cancer
1. [1]
  K. Ding, L. Shi, L. Zhang, et al., Polym. Chem. 7(2016) 899-904. doi: 10.1039/C5PY01690H
2. [2]
  K.C. Remant Bahadur, B. Thapa, P. Xu, Mol. Pharm. 9(2012) 2719-2729. doi: 10.1021/mp300274g
3. [3]
  K. Ulbrich, V. Subr, Adv. Drug Deliv. Rev. 56(2004) 1023-1050. doi: 10.1016/j.addr.2003.10.040
4. [4]
  D.E. Meyer, B.C. Shin, G.A. Kong, M.W. Dewhirst, A. Chilkoti, J. Control Release 74(2001) 213-224. doi: 10.1016/S0168-3659(01)00319-4
5. [5]
  M.R. Chilkoti, D.E. Dreher, D. Meyer, D. Raucher, Adv. Drug Deliver. Rev. 54(2002) 613-630. doi: 10.1016/S0169-409X(02)00041-8
6. [6]
  Y. Bansal, Y. Zhang, Acc. Chem. Res. 47(2014) 3052-3060. doi: 10.1021/ar500217w
7. [7]
  S. Barman, S.K. Mukhopadhyay, K.K. Behara, S. Dey, N.D. Singh, ACS Appl. Mater. Interfaces 6(2014) 7045-7054. doi: 10.1021/am500965n
8. [8]
  S. Karthik, N. Puvvada, B.N. Kumar, et al., ACS Appl. Mater. Interfaces 5(2013) 5232-5238. doi: 10.1021/am401059k
9. [9]
  A.Y. Rwei, W. Wang, D.S. Kohane, Nano Today 10(2015) 451-467. doi: 10.1016/j.nantod.2015.06.004
10. [10]
  J. Nunthanid, K. Huanbutta, M. Luangtana-anan, et al., Eur. J. Pharm. Biopharm. 68(2008) 253-259. doi: 10.1016/j.ejpb.2007.05.017
11. [11]
  M.R. Dzamukova, E.A. Naumenko, Y.M. Lvov, R.F. Fakhrullin, Sci. Rep. 5(2015) 10560. doi: 10.1038/srep10560
12. [12]
  W. Cheng, L. Gu, W. Ren, Y. Liu, Mater. Sci. Eng. C 45(2014) 600-608. doi: 10.1016/j.msec.2014.05.050
13. [13]
  Y.J. Jeon, W. Bang, Y.H. Choi, J.H. Shim, J.I. Chae, Biol. Pharm. Bull. 38(2015) 1302-1308. doi: 10.1248/bpb.b15-00159
14. [14]
  Z. Lv, P. Wang, X. Wang, X. Tang, Int. J. Mol. Sci. 13(2012) 16387-16399. doi: 10.3390/ijms131216387
15. [15]
  Z. Lv, P. Wang, X. Wang, X. Tang, Langmuir 28(2012) 9387-9394. doi: 10.1021/la301534h
16. [16]
  K. Landfester, Angew. Chem. Int. Ed. 48(2009) 4488-4507. doi: 10.1002/anie.v48:25
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2. [2]
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13. [13]
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20. [20]
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