Citation: Zhao Fen, Liu Yunbao, Ma Shuanggang, Yu Dequan, Yu Shishan. New compounds from the roots of Coriaria nepalensis[J]. Chinese Chemical Letters, ;2018, 29(3): 467-470. doi: 10.1016/j.cclet.2017.10.009 shu

New compounds from the roots of Coriaria nepalensis

Zhao Fen ^a,b ,
Liu Yunbao ^a ,
Ma Shuanggang ^a ,
Yu Dequan ^a ,
Yu Shishan ^a,,

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology & Business University, Beijing 100048, China

Corresponding author: Yu Shishan, yushishan@imm.ac.cn
Received Date: 18 April 2017
Revised Date: 5 October 2017
Accepted Date: 11 October 2017
Available Online: 13 March 2017

Figures(4)

One new sesquiterpene lactone, corialactone E (1), one new neolignan, coriarianeolignan A (2), together with three known apocarotenoids (3-5) and one known neolignan (6) have been isolated from a CHCl₃ extract of the roots of Coriaria nepalensis. The structures including absolute configurations of 1-6 were elucidated through extensive NMR, HR-ESIMS, and CD data analysis. Structurally, compound 1 possessed novel variations in the structure, including the newly formed ether ring of C-3/O/C-9 and the lactone ring connecting C-13 and C-5. Compound 5 showed cytotoxic activity against SKOV3 (human ovarian cancer) cells with IC₅₀ values of 4.67μmol/L. In vivo system, compound 3 showed anti-convulsant activity by 34% at the dose of 5 mg/kg.
- Coriaria nepalensis,
- Sesquiterpene,
- Lactone,
- Neolignan,
- Cytotoxicity,
- Anti-convulsant
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