Citation: Wang Wen, Tekcham Dinesh Singh, Yan Min, Wang Zhichao, Qi Huan, Liu Xiaolong, Piao Hai-Long. Biochemical reactions in metabolite-protein interaction[J]. Chinese Chemical Letters, ;2018, 29(5): 645-647. doi: 10.1016/j.cclet.2017.10.002 shu

Biochemical reactions in metabolite-protein interaction

Wang Wen ^a,b,c ,
Tekcham Dinesh Singh ^a ,
Yan Min ^a,b,c ,
Wang Zhichao ^a,b,c ,
Qi Huan ^a ,
Liu Xiaolong ^a ,
Piao Hai-Long ^a,b,,

a.
Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Corresponding author: Piao Hai-Long, hpiao@dicp.ac.cn
Received Date: 12 July 2017
Revised Date: 21 September 2017
Accepted Date: 10 October 2017
Available Online: 13 May 2017

Figures(1)

Active endogenous metabolites regulate the viability of cells. This process is controlled by a series of interactions between small metabolites and large proteins. Previously, several studies had reported that metabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulation of the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditional biochemical methods are insufficient to systematically investigate the bio-molecular reactions for a highthroughput discovery. Here, we have reviewed an update on the recently developed chemical proteomics called activity-based protein profiling (ABPP). ABPP is able to identify proteins interacted either covalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characterization of specific metabolite regulating proteins in human disease progression.
- Post translational modification,
- Activity-based protein profiling,
- Metabolite-protein interaction,
- Chemical probe,
- Mass spectrometry
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