Citation: Li Shuihong, Leung Polly H.M., Xu Xinya, Wu Chunhui. Homogentisic acid γ-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules[J]. Chinese Chemical Letters, ;2018, 29(2): 313-316. doi: 10.1016/j.cclet.2017.09.052 shu

Homogentisic acid γ-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules

a.
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China
b.
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China
c.
Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
d.
Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu 610054, China

Corresponding author: Leung Polly H.M., polly.hm.leung@polyu.edu.hk
Received Date: 6 July 2017
Revised Date: 19 September 2017
Accepted Date: 22 September 2017
Available Online: 23 February 2017

Figures(4)

Bacterial quorum sensing (QS) molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules (autoinducers) and their corresponding receptors have been recognized as important therapeutic targets for drug-resistant infections and biofilm-associated infections (BAI). This study assessed the multiple biological effects of homogentisic acid γ-lactone (HgAL), a furanone derivative. The anti-QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSM, SEM, HPLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of Pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C₁₂-HSL and C₄-HSL (two kinds of QS signaling molecules in P. aeruginosa). Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings.
- Homogentisic acid γ-lactone,
- Quorum sensing,
- Biofilm,
- Pseudomonas aeruginosa,
- Pyocyanin
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1.
沈阳化工大学材料科学与工程学院沈阳 110142