Citation: Qiu Liang, Zhao Linfei, Xing Chengfen, Zhan Yong. Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery[J]. Chinese Chemical Letters, ;2018, 29(2): 301-304. doi: 10.1016/j.cclet.2017.09.048 shu

Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

Institute of Biophysics, Hebei University of Technology, Tianjin 300401, China

Corresponding author: Xing Chengfen, xingc@hebut.edu.cn
Received Date: 20 June 2017
Revised Date: 22 September 2017
Accepted Date: 22 September 2017
Available Online: 23 February 2017

Figures(5)

A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[(2-((2-((camptothecin)-oxy)ethyl)disulfanyl)ethylmethacrylate)-co-(2-(D-galactose)methylmethacryl-ate)] (P (MACPTS-co-MAGP)) and AgNPs is developed to deliver the anti-cancer drug camptothecin (CPT) and monitor the drug release by the recovery of the fluorescence of CPT. CPT is linked to the polymer sidechains via a redox-responsive disulfide bond, attaching on the surface of AgNPs and leading to the quenching of CPT fluorescence ("off" state) due to the nanoparticle surface energy transfer (NSET) effect. Upon the exposure to glutathione (GSH), the disulfide bond is cleaved to release CPT, resulting in the recovery of the fluorescence of CPT ("on" state). The system offers a platform to track the CPT delivery and releasing in real time
- Redox-responsive,
- Drug delivery system,
- Hybrid nanoparticles,
- NSET effect
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