Citation: Tan Xiang-mei, Chen Amanda Juan, Wu Bin, Zhang Gui-Shan, Ding Gang. Advance of swainsonine biosynthesis[J]. Chinese Chemical Letters, ;2018, 29(3): 417-422. doi: 10.1016/j.cclet.2017.08.040 shu

Advance of swainsonine biosynthesis

a.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
b.
Key Laboratory of Microbial Resources Collection and Preservation, Ministry of Agriculture, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Corresponding author: Ding Gang, gding@implad.ac.cn
Received Date: 28 June 2017
Revised Date: 24 July 2017
Accepted Date: 22 August 2017
Available Online: 26 March 2017

Figures(9)

Swainsonine (1) belongs to the family of indolizine alkaloid with strong neurologically toxic effects on herbivorous livestock. Recently, a great amount of evidence confirmed that this alkaloid displayed a wide range of bioactivities especially anti-cancer biological effects. The potential targets of swainsonine (1) were now revealed to be the mannosidase and Golgi mannosidase Ⅱ. Its low yield in plants or fungi, and no economically total synthesis route in practice as the key bottleneck restricted its further structureactivities relationships (SAR) investigation in drug discovery. This mini-review highlighted the biosynthetic advance of swainsonine (1) from 1973 to 2017 based on the results of isotope-labelled experiments and the recent research of its biosynthetic gene cluster, which could provide some thoughts for further biosynthetic investigation and efficiently biomimetic synthesis of swainsonine (1) in order to increase its output in practice.
- Swainsonine,
- Indolizine,
- Biosynthesis,
- Isotope-labeled,
- Gene Cluster
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