Citation: Zhang Rui, Tang Chunping, Ke Chang-Qiang, Yao Sheng, Lin Ge, Ye Yang. Birhodomolleins D and E, two new dimeric grayanane diterpenes with a 3-O-2' linkage from the fruits of Rhododendron pumilum[J]. Chinese Chemical Letters, ;2018, 29(1): 123-126. doi: 10.1016/j.cclet.2017.07.009 shu

Birhodomolleins D and E, two new dimeric grayanane diterpenes with a 3-O-2' linkage from the fruits of Rhododendron pumilum

Zhang Rui ^a,b,c ,
Tang Chunping ^a,c ,
Ke Chang-Qiang ^a,c ,
Yao Sheng ^a,c ,
Lin Ge ^c,d ,
Ye Yang ^a,c,e,,

a.
State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
SIMM-CUHK Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, Chinese Academy of Sciences and The Chinese University of Hong Kong, Hong Kong SAR, China
d.
School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
e.
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Corresponding author: Ye Yang, yye@simm.ac.cn
Received Date: 5 April 2017
Revised Date: 5 May 2017
Accepted Date: 5 July 2017
Available Online: 11 January 2017

Figures(4)

Two new dimeric diterpenes, birhodomolleins D (1) and E (2), were characterized from the fruits of Rhododendron pumilum. Their structures featured two grayanane diterpenes dimerized through an oxygen bridge locating at C-3 and C-2'. They are the first examples of dimeric grayanane diterpenes with a 3-O-2' linkage from the Ericaceae family. Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data.
- Rhododendron pumilum,
- Ericaceae,
- Dimeric diterpene,
- Grayanane,
- Birhodomollein D,
- Birhodomollein E
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