Citation: Shi Xiaodong, Jiang Yixiang, Yang Dan, Zhao Hui, Tian Yuan, Li Zigang. Reversibly switching the conformation of short peptide through in-tether chiral sulfonium auxiliary[J]. Chinese Chemical Letters, ;2018, 29(3): 485-488. doi: 10.1016/j.cclet.2017.07.003 shu

Reversibly switching the conformation of short peptide through in-tether chiral sulfonium auxiliary

Shi Xiaodong ^a,1 ,
Jiang Yixiang ^a,1 ,
Yang Dan ^a,1 ,
Zhao Hui ^a ,
Tian Yuan ^a,b,**,, ,
Li Zigang ^a,,

a.
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
b.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 611756, China

Corresponding author: Tian Yuan, ty@swjtu.edu.cn Li Zigang, lizg@pkusz.edu.cn

^**

Received Date: 16 May 2017
Revised Date: 22 May 2017
Accepted Date: 3 July 2017
Available Online: 15 March 2017

Figures(5)

A chirality induced helicity method has been developed to modulate the peptide's biophysical and biochemical properties. We report herein a novel approach for reversibly switching the conformation of short constraint α-helical peptides through alkylation of the in-tether thioether and dealkylation of the chiral sulfonium. This traceless redox sensitive tagging strategy broadened our scope of CIH (chirality induced helicity) strategy and provided a valuable approach to functionalize the peptide tether.
- Cyclic peptide,
- Sulfonium,
- Chiral center,
- α-Helix,
- Reversible,
- Tether modification
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