Citation: Shi Jian-Jun, Ren Gui-Hua, Wu Ning-Jie, Weng Jian-Quan, Xu Tian-Ming, Liu Xing-Hai, Tan Cheng-Xia. Design, synthesis and insecticidal activities of novel anthranilic diamides containing polyfluoroalkyl pyrazole moiety[J]. Chinese Chemical Letters, ;2017, 28(8): 1727-1730. doi: 10.1016/j.cclet.2017.05.015 shu

Design, synthesis and insecticidal activities of novel anthranilic diamides containing polyfluoroalkyl pyrazole moiety

a.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
b.
School of Chemistry and Chemical Engineering, Huangshan University, Huangshan 245041, China
c.
Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China

Corresponding author: Liu Xing-Hai, xhliu@zjut.edu.cn Tan Cheng-Xia, tanchengxia@zjut.edu.cn
Received Date: 3 February 2017
Revised Date: 27 March 2017
Accepted Date: 7 April 2017
Available Online: 17 August 2017

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In order to discover new molecules with good insecticidal activities, a series of anthranilic diamides containing polyfluoroalkyl pyrazole were designed and synthesized, and their structures were characterized by ¹H NMR and HRMS. Bioassays demonstrated that some of the title compound exhibited excellent insecticidal activities. The larvicidal activities of compound 8a, 8c, 8g, 8k and 8l against Mythimna separata Walker were 100% at 0.8 mg/L. The insecticidal activities of compound 8a, 8c, 8e, 8g, 8k and 8l against Plutella xylostella Linnaeus were 100% at 0.4 mg/L. Surprisingly compounds 8a and 8c still showed 100% larvicidal activities against Plutella xylostella Linnaeus at 0.08 mg/L comparable to the commercialized Chlorantraniliprole. The LC₅₀ of compound 8a and 8c against M. separata is 0.048 and 0.043 mg/L respectively.
- Polyfluoroalkyl pyrazole carboxamide,
- Insecticidal activity,
- Chlorantraniliprole,
- Ryanodine receptors
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