Citation: Gao Yuan, Xiao Wei, Liu Hong-Chun, Wang Jian-Rong, Yao Li-Gong, Ouyang Ping-Kai, Wang De-Cai, Guo Yue-Wei. Clavirolide G, a new rare dolabellane-type diterpenoid from the Xisha soft coral Clavularia viridis[J]. Chinese Chemical Letters, ;2017, 28(4): 905-908. doi: 10.1016/j.cclet.2017.01.004 shu

Clavirolide G, a new rare dolabellane-type diterpenoid from the Xisha soft coral Clavularia viridis

a.
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
b.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
c.
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China

Corresponding author: Wang De-Cai, dcwang@njtech.edu.cn Guo Yue-Wei, ywguo@simm.ac.cn
Received Date: 27 December 2016
Revised Date: 30 December 2016
Accepted Date: 30 December 2016
Available Online: 9 April 2017

Figures(3)

One new dolabellane-type diterpenoid, named clavirolide G(1), and one known related analogue(3), have been isolated from the soft coral Clavularia viridis collected off the Xisha Islands in the South China Sea.Its structure and absolute configuration were determined on the basis of spectroscopic analysis, electronic circular dichroism, and compared with literature model compounds.The cytotoxic activity of these two compounds was evaluated against a panel of human tumor cell lines.Compound 1 showed moderate cytotoxic activity against KB and HL-60 cells.
- Soft coral,
- Clavularia viridis,
- Dolabellane diterpenoid,
- Cytotoxic activity
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1.
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