Citation: Mohebat Razieh, Yazdani-Elah-Abadi Afshin, Maghsoodlou Malek-Taher, Hazeri Nourallah. DABCO-catalyzed multi-component domino reactions for green and efficient synthesis of novel 3-oxo-3H-benzo[a]pyrano[2, 3-c] phenazine-1-carboxylate and 3-(5-hydroxybenzo[a]phenazin-6-yl) acrylate derivatives in water[J]. Chinese Chemical Letters, ;2017, 28(5): 943-948. doi: 10.1016/j.cclet.2016.12.042 shu

DABCO-catalyzed multi-component domino reactions for green and efficient synthesis of novel 3-oxo-3H-benzo[a]pyrano[2, 3-c] phenazine-1-carboxylate and 3-(5-hydroxybenzo[a]phenazin-6-yl) acrylate derivatives in water

a.
Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran
b.
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

Corresponding author: Yazdani-Elah-Abadi Afshin, afi_yazdani@yahoo.com Maghsoodlou Malek-Taher, mt_maghsoodlou@yahoo.com; mt_maghsoodlou@chem.usb.ac.ir
Received Date: 24 October 2016
Revised Date: 29 November 2016
Accepted Date: 7 December 2016
Available Online: 8 May 2017

Figures(4)

An efficient, convenient and environmentally benign procedure for the synthesis of novel 3-oxo-3H-benzo[a]pyrano[2, 3-c]phenazine-1-carboxylate and 3-(5-hydroxybenzo[a]phenazin-6-yl)acrylate derivatives has been developed by domino three-component condensation reaction between 2-hydroxynaphthalene-1, 4-dione, benzene-1, 2-diamines and acetylenic esters in the presence of a catalytic amount of DABCO as an expedient, eco-friendly and reusable base catalyst in water. This green process produces biologically and pharmacologically significant heterocycles in a one-pot single operation and offers considerable advantages such as:operational simplicity, short reaction time, high yields, reusability of catalyst, absence of any tedious workup or purification and avoids hazardous reagents/solvents.
- Multi-component domino reactions (MDRs),
- DABCO,
- Acetylenic esters,
- Benzo[a]phenazin derivatives,
- Green chemistry
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