Citation: Cui Hao-Dong, Hu De-Hong, Zhang Jing-Nan, Gao Guan-Hui, Zheng Cui-Fang, Gong Ping, Xi Xing-Hua, Sheng Zong-Hai, Cai Lin-Tao. Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy[J]. Chinese Chemical Letters, ;2017, 28(7): 1391-1398. doi: 10.1016/j.cclet.2016.12.038 shu

Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy

Cui Hao-Dong ^a,b ,
Hu De-Hong ^a,c ,
Zhang Jing-Nan ^a ,
Gao Guan-Hui ^d ,
Zheng Cui-Fang ^a ,
Gong Ping ^a ,
Xi Xing-Hua ^e ,
Sheng Zong-Hai ^a,c,*,, ,
Cai Lin-Tao ^a,*,,

a.
Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese of Academy ofSciences, Shenzhen 518055, China
b.
Department of Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China
c.
Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese of Academy of Sciences, Shenzhen 518055, China
d.
Paul-Drude-Institut für Festkörperelektronik, Berlin 10117, Germany
e.
Department of Ophthalmology, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan Univiersity, Shenzhen 518020, China

Corresponding author: Sheng Zong-Hai, zh.sheng@siat.ac.cn Cai Lin-Tao, lt.cai@siat.ac.cn

Received Date: 23 August 2016
Revised Date: 17 November 2016
Accepted Date: 1 December 2016
Available Online: 8 July 2017

Figures(5)

As one of near-infrared (NIR) fluorescent (FL) nanoprobes, gold nanoclusters (Au NCs) are delicated to passive-targeting tumors for NIR FL imaging, but which easily cleared by the kidneys for the small size ( < 1.5 nm). Herein, the well-defined gold clusters nanoassembly (Au CNA) was synthesized by the selfassembly of Au NCs based on protein cross-linking approach. The as-prepared Au CNA demonstrated highly effective cellular uptake and precise tumor targeting compared to that of Au NCs. Moreover, with the irradiation of 660 nm laser, Au CNA generated largely reactive oxygen species (ROS) for photodynamic therapy (PDT). In vitro and in vivo PDT revealed that Au CNA exhibited largely cell death and significantly tumor removal at a low power density of 0.2 W/cm². It could be speculated that the laser-excited Au CNA produced photon energy, which further obtained electron from oxygen to generate radical species. Therefore, Au CNA as a photosensitizer could realize NIR FL imaging and NIR laser induced PDT.
- Gold nanoclusters,
- Self-assembly,
- Near-infrared fluorescent nanoprobe,
- In vivo imaging,
- Photodynamic therapy
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