Citation: Liu Yang, Dong Chang-Ming. Effect of chirality on conformation and cellular uptake of poly(S-(o-nitrobenzyl)-L, D-cysteine)polypeptides[J]. Chinese Chemical Letters, ;2017, 28(4): 827-831. doi: 10.1016/j.cclet.2016.11.006 shu

Effect of chirality on conformation and cellular uptake of poly(S-(o-nitrobenzyl)-L, D-cysteine)polypeptides

Liu Yang ,
Dong Chang-Ming ^,

Department of Polymer Science & Engineering, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding author: Dong Chang-Ming, cmdong@sjtu.edu.cn
Received Date: 11 October 2016
Revised Date: 28 October 2016
Accepted Date: 1 November 2016
Available Online: 11 April 2016

Figures(5)

A series of poly(S-(o-nitrobenzyl)-L, D-cysteine)polypeptides with different chirality was synthesized and their molecular structures, secondary conformations, drug release and biological properties were thoroughly investigated.The chirality of the polypeptides had effect on secondary conformations and the cellular uptake behavior of the related nanoparticles.
- Chiral polypeptide,
- Secondary conformation,
- Nanoparticle,
- Drug release,
- Cellular uptake
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