Citation: Yong Li, Jie Lei, Jia Xu, Dian-Yong Tang, Zhong-Zhu Chen, Jin Zhu, Chuan Xu. A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction[J]. Chinese Chemical Letters, ;2017, 28(3): 541-545. doi: 10.1016/j.cclet.2016.10.027 shu

A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction

Yong Li ^a,b ,
Jie Lei ^a,b ,
Jia Xu ^a,b ,
Dian-Yong Tang ^b ,
Zhong-Zhu Chen ^b,, ,
Jin Zhu ^a,b ,
Chuan Xu ^c,,

a.
Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
b.
Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China
c.
Department of Oncology, Chengdu Military General Hospital, Chengdu 610083, China

Corresponding author: Zhong-Zhu Chen, 18883138277@163.com Chuan Xu, 1535486239@qq.com
Received Date: 8 August 2016
Revised Date: 11 October 2016
Accepted Date: 14 October 2016
Available Online: 26 March 2016

Figures(4)

A series of quinolino[3, 4-b]quinoxalin-6(5H)-ones have been synthesized using an Ugi/deprotection/cyclization (UDC) strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3, 4-b]quinoxalin-6(5H)-ones for high-throughput screening in medicinal chemistry.
- Quinoxaline,
- Quinolino[3, 4-b]quinoxalin-6(5H)-one,
- Ugi/deprotection/cyclization (UDC) strategy,
- Nucleophilic substitution reaction,
- One-pot
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