Citation: Qi Wen-Jie, Han Ying, Liu Chang-Zhou, Yan Chao-Guo. Three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans[J]. Chinese Chemical Letters, ;2017, 28(2): 442-445. doi: 10.1016/j.cclet.2016.09.014 shu

Three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile for diastereoselective synthesis of densely substituted 2,3-dihydrofurans

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Corresponding author: Han Ying, hanying@yzu.edu.cn Yan Chao-Guo, cgyan@yzu.edu.cn
Received Date: 24 June 2016
Revised Date: 5 August 2016
Accepted Date: 30 August 2016
Available Online: 1 March 2016

Figures(3)

The three-component reaction of triphenylphosphine, dialkyl but-2-ynedioate and arylidene pivaloylacetonitrile in dry methylene dichloride at room temperature resulted in unexpected densely substituted 1-(triphenyl-λ⁵-phosphanylidene)ethyl)-2,3-dihydrofurans in satisfactory yields with high diastereoselectivity. The relative configuration of the 2,3-dihydrofurans was elucidated by determination of single crystal structures.
- Multicomponent reaction,
- Triphenylphosphine,
- But-2-ynedioate,
- Pivaloylacetonitrile,
- 2,3-Dihydrofuran
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