Citation: . Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum[J]. Chinese Chemical Letters, ;2017, 28(2): 358-361. doi: 10.1016/j.cclet.2016.09.012 shu

Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum

Received Date: 21 June 2016
Revised Date: 23 July 2016
Accepted Date: 29 August 2016
Available Online: 23 February 2016

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Four new diterpenoid alkaloids, nagaconitines A-D (1-4), were isolated from the roots of Aconitum nagarum var. heterotrichum. Their structures were elucidated as 8-(4'-hydroxylbutyryl) aconitine (1), 15-oxo-13-deoxyludaconitine (2), 15-hydroxyldelphisine (3), and 14-hydroxyl-2-acetoxyspiradine C (4) based on extensive UV, IR, MS, 1D NMR and 2D NMR analyses. Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31% (IC₅₀ 43.78 μmol/L) and 24% (IC₅₀ 32.14 μmol/L), respectively.
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