Citation: Chen Zhi, Shi Xiao-Xiao, Ge Dong-Qin, Jiang Zhen-Zhen, Jin Qi-Qi, Jiang Hua-Jiang, Wu Jia-Shou. Facile synthesis of indoles by K₂CO₃ catalyzed cyclization reaction of 2-ethynylanilines in water[J]. Chinese Chemical Letters, ;2017, 28(2): 231-234. doi: 10.1016/j.cclet.2016.07.022 shu

Facile synthesis of indoles by K₂CO₃ catalyzed cyclization reaction of 2-ethynylanilines in water

School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, China

Corresponding author: Wu Jia-Shou, jsw79@sina.com
Received Date: 12 June 2016
Revised Date: 8 July 2016
Accepted Date: 12 July 2016
Available Online: 21 February 2016

Figures(3)

The cyclization reaction of 2-ethynyl-N-sulfonylanilides proceeded efficiently in water with the presence of a catalytic amount of K₂CO₃ under transition metal-free condition to give indoles in high yields. The recovery and reusability of the present catalytic system were investigated.
- 2-Ethynylanilines,
- Cyclization reaction,
- Indoles,
- Water,
- Potassium carbonate
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Facile synthesis of indoles by K2CO3 catalyzed cyclization reaction of 2-ethynylanilines in water

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Facile synthesis of indoles by K₂CO₃ catalyzed cyclization reaction of 2-ethynylanilines in water