Citation: Zhang Li-Li, Zhu Hui-Kun, Zhao Chun-Chang, Gu Xian-Feng. A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H₂S production[J]. Chinese Chemical Letters, ;2017, 28(2): 218-221. doi: 10.1016/j.cclet.2016.07.008 shu

A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H₂S production

a.
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China
b.
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China

Corresponding author: Zhao Chun-Chang, zhaocchang@ecust.edu.cn Gu Xian-Feng, xfgu@fudan.edu.cn
Received Date: 3 June 2016
Revised Date: 17 June 2016
Accepted Date: 29 June 2016
Available Online: 16 February 2016

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Most reported fluorescent probes have limitations in practical applications in living systems due to the strong autofluorescence background, construction of probes with near-infrared (NIR) fluorescence emission is an accessible approach for addressing this challenge. We here designed a NIR fluorescent probe for monitoring the endogenous production of H₂S in living cells. The designed probe showed significant NIR fluorescence turn-on response to H₂S with high selectivity, enabling the sensitive detection H₂S. Importantly, the probe could be applied in monitoring the endogenous production of H₂S in raw264.7 macrophages. This study showed that fluvastatin can promote the activity of cystathionine γ-lyase (CSE) for generation H₂S.
- Fluorescent probe,
- Near-infrared fluorescence emission,
- Endogenous H₂S detection,
- Fluvastatin
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H2S production

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通讯作者: 陈斌, bchen63@163.com

A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H₂S production