Citation: Meena Kalawati, Kumari Sudesh, M. Khurana Jitender, Malik Amita, Sharma Chetan, Panwar Harsh. One pot three component synthesis of spiro[indolo-3, 10'-indeno[1, 2-b] quinolin]-2, 4, 11'-triones as a new class of antifungal and antimicrobial agents[J]. Chinese Chemical Letters, ;2017, 28(1): 136-142. doi: 10.1016/j.cclet.2016.06.025 shu

One pot three component synthesis of spiro[indolo-3, 10'-indeno[1, 2-b] quinolin]-2, 4, 11'-triones as a new class of antifungal and antimicrobial agents

a.
Department of Chemistry, University of Delhi, Delhi 110007, India
b.
Dyal Singh College, University of Delhi, Lodhi Road, Delhi 110003, India
c.
Department of Dairy Microbiology, College of Dairy Science and Technology, Guru Angad Dev Veterinary and Animal Science University, Ludhiana 141004, India

Corresponding author: M. Khurana Jitender, jmkhurana1@yahoo.co; injmkhurana@chemistry.du.ac.in
Received Date: 12 April 2016
Revised Date: 19 May 2016
Accepted Date: 24 May 2016
Available Online: 29 January 2016

Figures(7)

A simple and efficient three component procedure has been developed for the synthesis of highly substituted spiro[indolo-3, 10'-indeno[1, 2-b]quinolin]-2, 4, 11'-triones by one pot three component condensation of enaminones, isatin and indane-1, 3-dione in ethanol:water (1:1) in presence of ceric ammonium nitrate (CAN) as catalyst. This method provides several advantages such as lesser reaction time, high yield of products and operational simplicity. The antimicrobial activity of some of the compounds has been investigated against six microbial strains, some of the tested compounds showed good antimicrobial activity.
- Multicomponent reactions,
- Isatin,
- Spirooxindole,
- Heterocycles,
- Antimicrobial activity
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1.
沈阳化工大学材料科学与工程学院沈阳 110142