Citation: Xu Cai-Xia, Ma Cun-Hua, Xiao Fu-Rong, Chen Hong-Wei, Dai Bin. Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride[J]. Chinese Chemical Letters, ;2016, 27(11): 1683-1685. doi: 10.1016/j.cclet.2016.04.019 shu

Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride

School of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi 832003, China

Corresponding author: Dai Bin, db_tea@shzu.edu.cn
Received Date: 18 February 2016
Revised Date: 19 April 2016
Accepted Date: 27 April 2016
Available Online: 11 November 2016

We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction conditions.This protocol does not involve any metal catalysts or additives.It is simple, inexpensive, and easy to prepare, and exhibits good reaction activity.The hydrochlorination proceeds smoothly to yield unique regioselective products via the Markovnikov addition rule.
- Hydrochlorination,
- Arylalkynes,
- Vinyl chlorides,
- Catalyst-free,
- Markovnikov addition
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