Citation: Jaggi Lal, Sushil K. Gupta, D. Thavaselvam, Dau D. Agarwal. Synthesis and pharmacological activity evaluation of curcumin derivatives[J]. Chinese Chemical Letters, ;2016, 27(7): 1067-1072. doi: 10.1016/j.cclet.2016.03.032 shu

Synthesis and pharmacological activity evaluation of curcumin derivatives

  • Corresponding author: Jaggi Lal, jaggitajagra@gmail.com
  • Received Date: 7 August 2015
    Revised Date: 22 January 2016
    Accepted Date: 24 February 2016
    Available Online: 31 July 2016

Figures(4)

  • Curcumin 3, 4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.
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