Citation: Min Zhang, Ji-Mei Liu, Jin-Lian Zhao, Ning Li, Ri-Dao Chen, Ke-Bo Xie, Wen-Jing Zhang, Ke-Ping Feng, Zheng Yan, Nan Wang, Jun-Gui Dai. Two new diterpenoids from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum[J]. Chinese Chemical Letters, ;2016, 27(6): 957-960. doi: 10.1016/j.cclet.2016.02.008 shu

Two new diterpenoids from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received Date: 11 December 2015
Revised Date: 1 January 2016

Fund Project: Thisworkwas financially supported by the Science & Technology Project of Guangdong Province (No. 2011A080403020).

Two new harziane diterpenoids, named (9R,10R)-dihydro-harzianone (1) and harzianelactone (2), were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic (HR-ESI-MS, 1D NMR, 2D NMR and CD) analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer-Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against HeLa and MCF-7 cell lines with IC50 values of 30.1 mmol/L and 30.7 mmol/L, respectively.
- Harziane diterpenoids,
- Trichoderma sp. Xy24,
- Endophytic fungus,
- Mangrove plant,
- Cytotoxic activity
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