Design, synthesis and insecticidal activity of biphenyl-diamide derivatives

注册 English

Design, synthesis and insecticidal activity of biphenyl-diamide derivatives

Ye Liu , Chao Lei , Xiao-Yong Xu , Xu-Sheng Shao , Zhong Li

Citation: Ye Liu, Chao Lei, Xiao-Yong Xu, Xu-Sheng Shao, Zhong Li. Design, synthesis and insecticidal activity of biphenyl-diamide derivatives[J]. Chinese Chemical Letters, 2016, 27(03): 321-324. doi: 10.1016/j.cclet.2015.12.011 shu

shu

Design, synthesis and insecticidal activity of biphenyl-diamide derivatives

1.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

通讯作者: Xu-Sheng Shao,
Zhong Li,

摘要: Diamides acting on insect ryanodine receptors are an intensive research area now. In order to search for novel candidates, a series of diamides containing biphenyl substructure were designed and synthesized. Their insecticidal activities against armyworms (Mythimna sepatara) and aphis (Aphis craccivora) were screened. The compounds with 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl substituent were found to be insecticidal to armyworms with the similar symptoms to poisoning by flubendiamide. In this research, we presented a novel type of diamide insecticide as a lead compound for further optimization.

关键词:

English

Design, synthesis and insecticidal activity of biphenyl-diamide derivatives

1.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Xu-Sheng Shao, Zhong Li,

Received Date: 29 April 2015
Available Online: 30 December 2015

Abstract: Diamides acting on insect ryanodine receptors are an intensive research area now. In order to search for novel candidates, a series of diamides containing biphenyl substructure were designed and synthesized. Their insecticidal activities against armyworms (Mythimna sepatara) and aphis (Aphis craccivora) were screened. The compounds with 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl substituent were found to be insecticidal to armyworms with the similar symptoms to poisoning by flubendiamide. In this research, we presented a novel type of diamide insecticide as a lead compound for further optimization.

Key words:

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