Citation: Wei Guo. Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants[J]. Chinese Chemical Letters, ;2016, 27(01): 47-50. doi: 10.1016/j.cclet.2015.09.012 shu

Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants

Wei Guo ^a,b,,

1.
a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;
2.
b Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China

Corresponding author: Wei Guo,
Received Date: 4 August 2015
Available Online: 26 August 2015
Fund Project: We are grateful to the China Postdoctoral Science Foundation Funded Project(No. 2014M562165) (No. 2014M562165)

A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants.
- C-H amination,
- Pyrimidines,
- Amidines,
- Cinnamaldehydes,
- Oxygen
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沈阳化工大学材料科学与工程学院沈阳 110142