Citation: M. Nibin Joy, Bhaskaran Savitha, Ayyiliyath M. Sajith, Yadav D. Bodke, Talavara Venkatesh, K. K. Abdul Khader, M. Syed Ali Padusha, A. Muralidharan. A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation[J]. Chinese Chemical Letters, ;2016, 27(01): 31-36. doi: 10.1016/j.cclet.2015.08.015 shu

A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

a Department of P.
a Department of P. G studies and Research in Industrial Chemistry, Kuvempu University, Shankaraghatta, Shimoga, Karnataka, India;
2.
b Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India;
c Organic Chemistry Division, School of Chemical Sciences, Kasaragod Govt.
c Organic Chemistry Division, School of Chemical Sciences, Kasaragod Govt. College, Kannur University, Kannur, India

Corresponding author: Ayyiliyath M. Sajith, Yadav D. Bodke,
Received Date: 25 June 2015
Available Online: 3 August 2015

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of(A-^taphos)₂PdCl₂ as a catalyst in combination with CsF as base and DME-H₂O(4:1) as the solvent system at 100℃ procured the diaryls in acceptable to excellent yields. Prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.
- Imidazopyrazine,
- Boronic acid,
- Suzuki coupling,
- Microwave
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