Citation: Mehrnoosh Kangani, Malek-Taher Maghsoodlou, Nourallah Hazeri. Vitamin B12:An efficient type catalyst for the one-pot synthesis of 3,4,5-trisubstituted furan-2(5H)-ones and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates[J]. Chinese Chemical Letters, ;2016, 27(01): 66-70. doi: 10.1016/j.cclet.2015.07.025 shu

Vitamin B12:An efficient type catalyst for the one-pot synthesis of 3,4,5-trisubstituted furan-2(5H)-ones and N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates

1.
Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

Corresponding author: Malek-Taher Maghsoodlou,
Received Date: 12 June 2015
Available Online: 7 July 2015

Vitamin B12 was applied as catalyst for the one-pot three-component synthesis of 3,4,5-trisubstituted furan-2(5H)-ones from the condensation between aldehydes, amines and dialkylacetylendicarboxylates at ambient temperature in EtOH. In addition, N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates were synthesised using mentioned catalyst at ambient temperature in EtOH from condensation between formaldehyde, amines, and dialkylacetylenedicarboxylates. This methodology has number of advantages such as:use of green and nonhazardous catalyst, clean work up, short reaction times, high yields and no need to column chromatography.
- Vitamin B12,
- 3,4,5-Trisubstituted furan-2(5H)-ones,
- N-aryl-3-aminodihydropyrrol-2-one-4-,
- carboxylates
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