Citation: Li-Yan Liu, Yi-Zhe Yan, Ya-Jie Bao, Zhi-Yong Wang. Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes[J]. Chinese Chemical Letters, ;2015, 26(10): 1216-1220. doi: 10.1016/j.cclet.2015.07.008 shu

Efficient synthesis of 2-arylquinazolines via copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes

1.
Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei 230026, China

Corresponding author: Zhi-Yong Wang,
Received Date: 5 May 2015
Available Online: 19 June 2015
Fund Project: We are grateful to the National Nature Science Foundation of China (Nos. 2127222, 91213303, 21172205, 21432009, 21472177). (Nos. 2127222, 91213303, 21172205, 21432009, 21472177)

A novel copper-catalyzed dual oxidative benzylic C-H aminations of methylarenes with 2- aminobenzoketones in the presence of ammonium acetate was developed. This reaction represents a new avenue for 2-arylquinazolines with good yields. A key intermediate was detected and the kinetics isotope effect (KIE) indicated that C-H bond cleavage was the rate-determining step.
- Quinazolines,
- Copper,
- C-H aminations,
- Methylarenes
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